Stem-cell therapy led to a significant and visible improvement in follicular hair growth. New hair grew effectively using human pluripotent stem cells, cells derived from human embryos or human fetal tissue that can become any other cell type in the body.
Stem cell therapy is the use of stem cells to treat or prevent a disease or condition. Bone marrow transplant is the most widely used stem cell therapy. Bone-marrow has been used to treat cancer patients with conditions such as leukaemia and lymphoma. Stem cell treatment protocols employ well-targeted combinations of allogeneic human umbilical cord stem cells, autologous bone marrow stem cells, and autologous adipose stem cells, and to treat the diseases.
Regenerative medicine is a branch of translational research in tissue engineering and molecular biology which deals with the process of replacing, engineering or regenerating human cells, tissues or organs to restore or establish normal function.
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Regenerative medicine also includes the possibility of growing tissues and organs in the laboratory and safely implanting them when the body cannot heal itself. Examples include the injection of stem cells or progenitor cells obtained through Directed differentiation.
Adult stem cells are undifferentiated cells found throughout the body that divide to replenish dying cells and regenerate damaged tissues. An adult stem cell is an unspecialised cell that is capable of Long term renewal and Differentiation into specialised cell types. The primary function of adult somatic stem cells is to maintain tissue homeostasis by replenishing senescent or damaged cells. They are also known as somatic stem cells, they can be found in children, as well as adults. The endocrine pancreas represents an interesting arena for regenerative medicine and cell therapeutics.
Molecular regulation of embryonic stem cell fate involves a coordinated interaction between epigenetic transcriptional and translational mechanisms. It is unclear how these different molecular regulatory mechanisms interact to regulate changes in stem cell fate. Please go through the Journal highlights for more relevant fields of Stem Cell which can be considered for publication within the scope of Journal.
Isoforms of DeltaNp63 and the migration of ocular limbal cells in human corneal regeneration. USA , — Q-FIHC: quantification of fluorescence immunohistochemistry to analyse p63 isoforms and cell cycle phases in human limbal stem cells. Le, Q. The diagnosis of limbal stem cell deficiency. Dong, Y. Emerging therapeutic strategies for limbal stem cell deficiency.
Fine, J. Inherited epidermolysis bullosa: updated recommendations on diagnosis and classification. Carulli, S. The long and winding road that leads to a cure for epidermolysis bullosa.
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Mavilio, F. Correction of junctional epidermolysis bullosa by transplantation of genetically modified epidermal stem cells. Bauer, J. Closure of a large chronic wound through transplantation of gene-corrected epidermal stem cells. Siprashvili, Z. Safety and wound outcomes following genetically corrected autologous epidermal grafts in patients with recessive dystrophic epidermolysis bullosa.
Informed consent for stem cell research: why it matters and what you should know
A single type of progenitor cell maintains normal epidermis. Distinct contribution of stem and progenitor cells to epidermal maintenance. Comai, G. Molecular and cellular regulation of skeletal myogenesis. Miquerol, L. Organogenesis of the vertebrate heart. Wiley Interdiscip. Buckingham, M. Tissue differentiation: a personal account of research on myogenesis and cardiogenesis.
Chang, N. Satellite cells: the architects of skeletal muscle. Mercola, M. Cardiac muscle regeneration: lessons from development. Genes Dev. Chong, J. Developmental origins and lineage descendants of endogenous adult cardiac progenitor cells. Stem Cell Res. Porrello, E. Transient regenerative potential of the neonatal mouse heart.
Chien, K. Regenerating the field of cardiovascular cell therapy. Mauro, A. Satellite cell of skeletal muscle fibers. Gene regulatory networks and transcriptional mechanisms that control myogenesis. Cell 28 , — Zammit, P. Muscle satellite cells adopt divergent fates: a mechanism for self-renewal? Rocheteau, P.
Stem cells: past, present, and future
A subpopulation of adult skeletal muscle stem cells retains all template DNA strands after cell division. Guiraud, S. The pathogenesis and therapy of muscular dystrophies. Genomics Hum. Partridge, T. Conversion of mdx myofibres from dystrophin-negative to -positive by injection of normal myoblasts.
Miller, R. Myoblast implantation in Duchenne muscular dystrophy: the San Francisco study. Muscle Nerve 20 , — Gussoni, E. Normal dystrophin transcripts detected in Duchenne muscular dystrophy patients after myoblast transplantation. Stem and progenitor cells in skeletal muscle development, maintenance, and therapy. Boyer, O.
Stem cell research: Trends in and perspectives on the evolving international landscape
Autologous myoblasts for the treatment of fecal incontinence: results of a phase 2 randomized placebo-controlled study MIAS. Peters, K.
click Autologous muscle derived cells for treatment of stress urinary incontinence in women.